![]() This accumulation leads to extended retention of THC which is then eliminated from the body at a relatively constant rate with an average elimination half-life being estimated at 18-30 hours. Because THC tends to be stored in fatty tissues, it accumulates faster than it can be eliminated in chronic repetitive smokers. ![]() Initially, THC is quickly absorbed into the body tissues and then is slowly released back into the blood stream where it is carried to the liver and metabolized. These water soluble metabolites, are readily excreted into the urine, with the inactive metabolite carboxy-THC-glucuronide being the predominant metabolite detected. These primary metabolites are subsequently conjugated to glucuronic acid to make them water soluble. ![]() Once in the blood, THC is bound to blood proteins and carried throughout the body where it is either absorbed into body tissues (including the brain, heart, and fat) or transformed by the liver into11-hydroxy-THC and carboxy-THC. Following oral ingestion, THC does not reach the bloodstream for approximately 1-1.5 hours. When marijuana is smoked, THC is rapidly absorbed through the lungs and enters the bloodstream in minutes. Other compounds such as delta-8-tetrahydrocannabinol also contribute to marijuana’s physiological and psychological effects. There are up to 60 cannabinoids in marijuana with delta- 9-tetrahydrocannabinol (THC) being the primary psychoactive constituent. One of the primary classes of compounds found in marijuana is called cannabinoids. While the leaves and flowers are typically dried and smoked, the psychoactive compounds can be extracted and concentrated for use in dabs and edibles. Marijuana is a preparation derived from the leaves and flowering tops of cannabis plants (Cannabis sativa) that is capable of producing psychoactive effects when ingested.
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